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  • Photo: Lark L A Coffey

    Lark L A Coffey- PhD
    Assistant Professor and Assistant Research Scientist
    Pathology, Microbiology & Immunology

    1 Shields Ave
    Davis, CA 95616

    +1 530 752 2946
    lcoffey@ucdavis.edu

       

    Research Focus

    Mosquito-borne virus ecology, evolution and emergence

    My research seeks to define patterns of mosquito-borne virus ecology and evolution so that shared features can be exploited to prevent emergence and mitigate disease in humans and animals.

    Specialty Focus

    Genetics of mosquito-borne viruses

    Transmission dynamics of mosquito-borne viruses

    Surveillance of mosquito-borne viruses

    Alphaviruses, flaviviruses

    RNA virus evolution

    Education

    2000 B.S. Biology, University of the South, Sewanee, Tennessee
    2005 Ph.D. Experimental Pathology, University of Texas Medical Branch, Galveston, Texas
    2011 Virology, Institut Pasteur, Paris, France
    2013 Virus Discovery, Blood Systems Research Institute/University of California San Francisco, California, San Francisco, California
    2014 Arbovirus ecology, evolution and genetics, University of California, Davis, Davis, California
    2016 Arbovirus ecology, evolution and genetics, University of California, Davis, Davis, California

    Honors and Awards

    2007-2009 Sigma Xi Scientific Honor Society
    2005-2008 Philippe Foundation International Scholar, Institut Pasteur, Paris, France
    2005 Zhou Sisters Academic Scholarship, University of Texas Medical Branch, Galveston, TX
    2002 Bodhan Nechay Academic Scholarship; University of Texas Medical Branch, Galveston, TX

    Licenses

    UC Davis Biomedical and Engineering Entrepreneurship Academy Graduate

    Active Research Grants

    Principal Investigator, Engineering high fidelity mutations to increase safety of live-attenuated alphavirus vaccines , (Principal Investigator), NIH NIAID

    Co-Investigator, Characterization of blood transfusion-transmission of Zika virus in macaques, Graham Simmons, Blood Systems Research Institute/UCSF (Principal Investigator), NIH NHLBI extension of Recipient Epidemiology and Donor Evaluation Study-III

    Co-Investigator, Macaque model of Zika virus infection, Koen Van Rompay (Principal Investigator), NIH NIAID

    Most Recent 10 Publications

    • Lark L A Coffey: Diagnosis of Fatal Human Case of St. Louis Encephalitis Virus Infection by Metagenomic Sequencing, California, 2016 2017 Chiu CY, Coffey LL, Murkey J, Symmes K, Sample HA, Wilson MR, Naccache SN, Arevalo S, Somasekar S, Federman S, Stryke D, Vespa P, Schiller G, Messenger S, Humphries R, Miller S, Klausner JD Diagnosis of Fatal Human Case of St. Louis Encephalitis Virus Infection by Metagenomic Sequencing, California, 2016 Emerg Infect Dis,
    • Lark L A Coffey: Relative analytical sensitivity of donor nucleic acid amplification technology screening and diagnostic real-time polymerase chain reaction assays for detection of Zika virus RNA 2017 Stone M, Lanteri MC, Bakkour S, Deng X, Galel SA, Linnen JM, Munoz-Jordan JL, Lanciotti RS, Rios M, Gallian P, Musso D, Levi JE, Sabino EC, Coffey LL, Busch MP Relative analytical sensitivity of donor nucleic acid amplification technology screening and diagnostic real-time polymerase chain reaction assays for detection of Zika virus RNA Transfusion,
    • Lark L A Coffey: Zika Virus Tissue and Blood Compartmentalization in Acute Infection of Rhesus Macaques 2017 Coffey LL, Pesavento PA, Keesler RI, Singapuri A, Watanabe J, Watanabe R, Yee J, Bliss-Moreau E, Cruzen C, Christe KL, Reader JR, von Morgenland W, Gibbons AM, Allen AM, Linnen J, Gao K, Delwart E, Simmons G, Stone M, Lanteri M, Bakkour S, Busch MP, Morrison J, Van Rompay KKA Zika Virus Tissue and Blood Compartmentalization in Acute Infection of Rhesus Macaques PLoS One,
    • Lark L A Coffey: West Nile Virus fitness costs in different mosquito species 2016 Coffey LL, Reisen WK West Nile Virus fitness costs in different mosquito species Trends Microbiol,
    • Lark L A Coffey: Reemergence of St. Louis Encephalitis Virus, California, 2016 White GS, Symmes K, Sun P, Fang Y, Garcia S, Steiner C, Smith K, Reisen WK, and Coffey LL. Reemergence of St. Louis Encephalitis Virus, California, Emerging Infectious Diseases,
    • Lark L A Coffey: Quenching of unincorporated amplification signal reporters in reverse-transcription loop-mediated isothermal amplification enabling bright, single-step, closed-tube, and multiplexed detection of RNA viruses 2016 Ball CS, Light YK, Koh CY, Wheeler SS, Coffey LL, Meagher RJ Quenching of unincorporated amplification signal reporters in reverse-transcription loop-mediated isothermal amplification enabling bright, single-step, closed-tube, and multiplexed detection of RNA viruses Anal Chem,
    • Lark L A Coffey: Reorganization and expansion of the nidoviral family Arteriviridae 2016 Kuhn JH, Lauck M, Bailey AL, Shchetinin AM, Vishnevskaya TV, Bào Y, Ng TF, LeBreton M, Schneider BS, Gillis A, Tamoufe U, Diffo Jle D, Takuo JM, Kondov NO, Coffey LL, Wolfe ND, Delwart E, Clawson AN, Postnikova E, Bollinger L, Lackemeyer MG, Radoshitzky SR, Palacios G, Wada J, Shevtsova ZV, Jahrling PB, Lapin BA, Deriabin PG, Dunowska M, Alkhovsky SV, Rogers J, Friedrich TC, O'Connor DH, Goldberg TL Reorganization and expansion of the nidoviral family Arteriviridae Arch Virol,
    • Lark L A Coffey: Surveillance for Western Equine Encephalitis, St. Louis Encephalitis, and West Nile Viruses using reverse transcription loop-mediated isothermal amplification 2016 Wheeler SS, Ball CS, Langevin SA, Fang Y, Coffey LL, Meagher RJ Surveillance for Western Equine Encephalitis, St. Louis Encephalitis, and West Nile Viruses using reverse transcription loop-mediated isothermal amplification PLoS One,
    • Lark L A Coffey: Chikungunya virus–Vector interactions 2014 Coffey LL, Failloux AB, Weaver SC. Chikungunya virus–Vector interactions Viruses,
    • Lark L A Coffey: Arboviral bottlenecks and challenges to maintaining diversity and fitness during mosquito transmission 2014 Forrester NL Coffey LL, Weaver SC Arboviral bottlenecks and challenges to maintaining diversity and fitness during mosquito transmission Viruses,

    Most Recent 5 Book Chapters

    2016 Coffey L: The Nature of Viruses, MacLachlan, NJ, Dubai, EJ, (ed), Fenner’s Veterinary Virology, London. 13-16.

    2016 Coffey LL, Weaver SC, Forrester N: Alphavirus Evolution, , Alphaviruses: Molecular Biology, Pathogenesis and Host Interactions. 21-26.

    2016 Forrester NL, Gutierrez S, Coffey LL: The Evolution and Transmission of Vector-Borne Viruses, Weaver, Denison, Roossinck, Vignuzzi, (ed), Virus Evolution: Current Research and Future Directions. 61-100.

    2008 Coffey LL: Togaviruses not associated with human disease, Mahy B, Van Regenmortel M, (ed), Encyclopedia of Virology, 3rd Edition, Oxford. 91-6.

    2004 Weaver SC, Coffey LL, Nussenzveig R, Ortiz D, Smith D: Vector Competence, Gillespie SH, Smith GL, Osbourn A, (ed), Vector Competence, Cambridge. 139-80.

    External Links

    Lab Website