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    Heather Knych- DVM, PhD, DACVCP
    Associate Professor of Clinical and Associate Professor of Clinical
    California Animal Health and Food Safety Lab
    Molecular Biosciences

    K.L. Maddy Equine Analytical Chemistry Laboratory
    Davis, CA 95616

    +1 530 752 8700
    hkknych@ucdavis.edu

       

    Research Focus

    Equine: pharmacokinetics/pharmacodynamics; drug metabolism; biomarkers

    Specialty Focus

    Equine pharmacology

    Education

    2010 Residency American College of Veterinary Clinical Pharmacology Residency, University of California, Davis, Davis, CA
    2008 PhD Pharmacology and Toxicology, University of California, Davis, Davis, CA
    2005 DVM , University of California, Davis, Davis, CA
    2000 MS Physiology, San Jose State University, San Jose, CA
    1997 BS Biochemistry and Cell Biology, University of California, San Diego, LaJolla, CA

    Licenses

    Diplomate of the American College of Veterinary Clinical Pharmacology
    DVM, California

    Active Research Grants

    Principal Investigator, Characterization of Intra-Articular Isoflupredone, (Principal Investigator), Grayson Jockey Club

    Co-Principal Investigator, Efficacy of Furosemide dosed 4- vs 24-hours pre-race, (Principal Investigator), Grayson Jockey Club Research Foundation

    Principal Investigator, Xylazine PK/PD Study in Horses, (Principal Investigator), Racing Medication and Testing Consortium

    Co-Principal Investigator, Pharmacokinetics of Simbadol in Red Tailed Hawks, David Guzman (Principal Investigator), Center for Companion Animal Health (Resident Grant)

    Most Recent 10 Publications

    • Heather Knych: Investigation of the selective androgen receptor modulators (SARMs) S1, S4 and S22 and their metabolites in equine plasma using high resolution mass spectrometry 2016 Hansson A, Knych H, Stanley S, Thevis M, Bondesson U, Hedeland M Investigation of the selective androgen receptor modulators (SARMs) S1, S4 and S22 and their metabolites in equine plasma using high resolution mass spectrometry Rapid Communications in Mass Spectrometry,
    • Heather Knych: Disposition of Isoflupredone Acetate in Plasma, Urine and Synovial Fluid Following Intra-Articular Administration to Exercised Thoroughbred Horses 2015 Knych HK, Harrison LM, White A, McKemie DS Disposition of Isoflupredone Acetate in Plasma, Urine and Synovial Fluid Following Intra-Articular Administration to Exercised Thoroughbred Horses Drug Testing and Analysis, doi 10.1002/dta.1834,
    • Heather Knych: Serum, milk, and tissue monensin concentrations in cattle with adequate and potentially toxic dietary levels of monensin: pharmacokinetics and diagnostic interpretation 2015 Puschner BP, Bautista AC, McKemie DS, Gallego SM, Woods LW, Moore CE, Knych HK Serum, milk, and tissue monensin concentrations in cattle with adequate and potentially toxic dietary levels of monensin: pharmacokinetics and diagnostic interpretation Journal of Veterinary Pharmacology and Therapeutics, doi: 10.1111/jvp.12284,
    • Heather Knych: Pharmacokinetics of guaifenesin following administration of multiple doses to exercised Thoroughbred horses 2015 Knych HK, Stanley SD, Benson D, Arthur RA Pharmacokinetics of guaifenesin following administration of multiple doses to exercised Thoroughbred horses Journal of Veterinary Pharmacology and Therapeutics, doi:10.1111/jvp.12287,
    • Heather Knych: Plasma concentrations, analgesic and physiological assessments in horses with chronic laminitis treated with two doses of oral tramadol 2015 Guedes A, Knych H, Hood D Plasma concentrations, analgesic and physiological assessments in horses with chronic laminitis treated with two doses of oral tramadol Veterinary Anaesthesia and Analgesia, doi:10.1111/evj.12448,
    • Heather Knych: Pharmacokinetics of detomidine following intravenous
or oral-transmucosal administration and sedative effects of the oral-transmucosal treatment in dogs 2015 Messenger KM, Hopfensperger M, Knych HK, Papich MG Pharmacokinetics of detomidine following intravenous or oral-transmucosal administration and sedative effects of the oral-transmucosal treatment in dogs Journal of American Veterinary Medical Association,
    • Heather Knych: Dextromethorphan and debrisoquine metabolism and polymorphism of the gene for cytochrome P450 isozyme 2D50 in Thoroughbreds 2015 Corado C, McKemie DS, Knych HK Dextromethorphan and debrisoquine metabolism and polymorphism of the gene for cytochrome P450 isozyme 2D50 in Thoroughbreds American Journal of Veterinary Research,
    • Heather Knych: Effects of acepromazine or dexmedetomidine on fentanyl disposition in dogs during recovery from isoflurane anesthesia 2015 Keating S, Kerr C, McDonell W, Valverde A, Johnson R, Knych H, Edginton A Effects of acepromazine or dexmedetomidine on fentanyl disposition in dogs during recovery from isoflurane anesthesia Veterinary Anaesthesia and Analgesia,
    • Heather Knych: Characterization of equine urinary metabolites of selective androgen receptor modulators (SARMs) S1, S4 and S22 for doping control purposes 2015 Hansson A, Knych H, Stanley S, Thevis M, Bondesson U, Hedeland M Characterization of equine urinary metabolites of selective androgen receptor modulators (SARMs) S1, S4 and S22 for doping control purposes Drug Testing and Analysis,
    • Heather Knych: Pharmacokinetics of a Single Subcutaneous Dose of Sustained Release Buprenorphine in Northern Elephant Seals (Mirounga Angustirostris) 2015 Molter C, Barbosa L, Johnson S, Chinnadurai S, Knych H, Wack R Pharmacokinetics of a Single Subcutaneous Dose of Sustained Release Buprenorphine in Northern Elephant Seals (Mirounga Angustirostris) Journal of Zoo and Wildlife Medicine,

    Most Recent 5 Book Chapters

    2014 Knych HK: Chapter 13: Analgesic Pharmacology, , Robinson's Current Therapy in Equine Medicine, 7th Edition. 55-57.