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  • Photo: Gregory Lanzaro

    Gregory Lanzaro- BS, MS, PhD
    Professor and Researcher
    Pathology, Microbiology & Immunology

    4225 VM3B
    Davis, CA 95616

    +1 530 752 5652
    gclanzaro@ucdavis.edu

       

    Research Focus

    Vector biology, population genetics. My overall research interest is in the population genetics of insect vectors of human and animal diseases. I have developed a program that pursues knowledge that may be applied to the control of vectorborne diseases but at the same time addresses critical issues in basic evolutionary genetics. My work has transitioned from classical population genetics to a more contemporary population genomics approach. Whereas the earlier work was based on analyses using genic markers, such as microsatellite DNA and single nucleotide polymorphisms, our current work applies next generation sequencing to study individual insect genomes, allowing us to explore problems with far greater depth and to address questions that were intractable just a few years ago. In parallel with our increasing use of genomics I have established a program in bioinformatics which is essential for both the management and analysis of the large body of data we are generating using next generation sequencing. I am pursuing this interest within the context of four major avenues of research: 1) Population genetics of the human malaria vector, Anopheles gambiae in west and central Africa: This work deals with describing the genetic structure of populations, understanding the forces responsible for this structure and how patterns of gene flow influence the distribution of traits critical to understanding and managing malaria transmission. I have been working at field sites in Africa since 1991 and my current program has been supported continuously since 1996 with support in the form of a series of R01 grants from NIH on which I serve as P.I. 2) Genome-wide association mapping (GWAS) in the mosquito Anopheles arabiensis, the most important malaria vector in east Africa: Our focus is to understand the genetic basis of two critically import behavioral phenotypes in this mosquito: host preference (animal vs human blood feeding) and adult resting behavior (indoor vs outdoor). This project is funded by NIH with me as the PI and in collaboration with the Ifakara Health Institute in Tanzania. 3) Interactions between the South American vector, Anopheles darlingi and the human malaria parasite Plasmodium vivax. We are using a genomics approach to identify innate immune pathway related genes that are associated with the mosquito's ability kill the malaria parasite in the mosquito before it becomes infective to man. This project is being funded by the Brazilian government through a program called Brazil Science without Borders and conducted in collaboration with the Oswaldo Cruz Institute in Belo Horizonte, Brazil and the National Institute of Amazon Research, Manaus, Brazil

    Specialty Focus

    Entomology, population genetics, genomics

    Education

    1972 BS Secondary Education, Kansas State University, Manhattan, Kansas
    1978 MS Entomology, University of Arizona, Tucson, Arizona
    1986 PhD Entomology, University of Florida, Gainesville, Florida
    1988 Post-doctoral , Mississippi State University, Starkville, MS
    1991 Post-doctoral , University of California, Davis,
    1995 MacArthur Fellow , National Institutes of Health,

    Honors and Awards

    2014 Award of Honour/Plenary Speaker, presented by Association of Entomologists, Department of Zoology and Environmental Sciences, Punjabi University
    2013 Delegate, Albert Schweitzer Centennial, Libreville, Gabon, Central Africa
    2013 Distinguished Service Award, Society for Vector Ecology
    2011 President, Society for Vector Ecology
    2010 President Elect
    2010 Plenary Speaker, Keystone Symposia on Molecular and Cell Biology
    2010 Keynote Speaker, 10th Annual Symposium, Center for Host-Parasite Interactions, McGill University
    2010 Keynote Speaker, 14th Annual Arthromint Meeting, Oswaldo Cruz Institute, Ilha Grande, Brazil
    2010 Invited Speaker, Biology of Mosquito Vectors Symposium, Johns Hopkins University
    2010 2010 Editor's Choice Award by the Entomological Society of America
    2009 Elected Vice-President/President Elect, Society for Vector Ecology
    2009 Plenary Speaker, 34th Annual Meeting, Human Biology Association
    2009 2009 Student Selected Speaker, Department of Entomology, University of Arkansas
    2007 Excellence in Research Award, Academic Federation, UC Davis
    2007 Plenary Speaker, Annual Meeting, Society of Vector Ecology
    2006 Service Award, Entomological Society of America
    2005 Rogoff Lectureship, Department of Entomology, Cornell University
    2002-2010 Member, External Advisory Panel, Johns Hopkins University Malaria Institute
    2000-2006 Faculty, International Biology of Disease Vectors Course
    1991-1995 MacArthur Foundation Fellowship, Molecular Biology of Disease Vectors

    Active Research Grants

    Co-Principal Investigator, Safely engineering various classes of gene drives to control a major invasive disease vector, Ae. aegypti., Omar Akbari, UCR (Principal Investigator), Defense Advanced Research Projects Agency (DARPA)

    Co-Principal Investigator, UC Irvine Malaria Initiative-Phase I, Anthony James, UCI (Principal Investigator), UC Irvine

    Principal Investigator, PI Bridge Program, (Principal Investigator), UCD Office of Research and School of Veterinary Medicine

    Most Recent 10 Publications

    • Gregory Lanzaro: The genetic basis of host preference and resting behavior in the major African malaria vector, Anopheles arabiensis 2016 Main BJ, Lee Y, Ferguson HM, Kreppel KS, Kihonda A, Govella NJ, Collier TC, Cornel AJ, Eskin E, Kang EY, Nieman CC, Weakley AM and Lanzaro GC. The genetic basis of host preference and resting behavior in the major African malaria vector, Anopheles arabiensis PLoS Genetics,
    • Gregory Lanzaro: Anopheles darlingi polytene chromosomes: revised maps including newly described inversions and evidence for population structure in Manaus 2016 Cornel AJ, Brisco KK, Tadei WP, Secundino NF, Rafael MS, Galardo AK, Medeiros JF, Pessoa FA, Ríos-Velásquez CM, Lee Y, Pimenta PF, Lanzaro GC Anopheles darlingi polytene chromosomes: revised maps including newly described inversions and evidence for population structure in Manaus Mem Inst Oswaldo Cruz,
    • Gregory Lanzaro: Investigating associations between biting time in the malaria vector Anopheles arabiensis Patton and single nucleotide polymorphisms in circadian clock genes: support for sub-structure among An. arabiensis in the Kilombero valley of Tanzania 2016 Maliti DV, Marsden CD, Main BJ, Govella NJ, Yamasaki Y, Collier TC, Kreppel K, Chiu JC, Lanzaro GC, Ferguson HM, Lee Y Investigating associations between biting time in the malaria vector Anopheles arabiensis Patton and single nucleotide polymorphisms in circadian clock genes: support for sub-structure among An. arabiensis in the Kilombero valley of Tanzania Parasit Vectors,
    • Gregory Lanzaro: Surveillance, insecticide resistance and control of an invasive Aedes aegypti (Diptera: Culicidae) population in California 2016 Cornel AJ, Holeman J, Nieman CC, Lee Y, Smith C, Amorino M, Brisco KK, Barrera R, Lanzaro GC, Mulligan Iii FS Surveillance, insecticide resistance and control of an invasive Aedes aegypti (Diptera: Culicidae) population in California F1000Res,
    • Gregory Lanzaro: Complex genome evolution in Anopheles coluzzii associated with increased insecticide usage in Mali 2015 Main BJ, Lee Y, Collier TC, Norris LC, Brisco K, Fofana A, Cornel AJ, Lanzaro GC Complex genome evolution in Anopheles coluzzii associated with increased insecticide usage in Mali Mol Ecol,
    • Gregory Lanzaro: Defining genetic, taxonomic, and geographic boundaries among species of the Psorophora confinnis (Diptera: Culicidae) complex in North and South America 2015 Lanzaro GC, Collier TC, Lee Y Defining genetic, taxonomic, and geographic boundaries among species of the Psorophora confinnis (Diptera: Culicidae) complex in North and South America J Med Entomol,
    • Gregory Lanzaro: Absence of kdr resistance alleles in the Union of the Comoros, East Africa 2015 Lee Y, Olson N, Yamasaki Y, Chang A, Marsden C, Ouledi A, Lanzaro GC, Cornel A Absence of kdr resistance alleles in the Union of the Comoros, East Africa F1000Res,
    • Gregory Lanzaro: A multi-detection assay for malaria transmitting mosquitoes 2015 Lee Y, Weakley AM, Nieman CC, Malvick J, Lanzaro GC A multi-detection assay for malaria transmitting mosquitoes J Vis Exp,
    • Gregory Lanzaro: Colonization of malaria vectors under semi-field conditions as a strategy for maintaining genetic and phenotypic similarity with wild populations 2015 Ng'habi KR, Lee Y, Knols BG, Mwasheshi D, Lanzaro GC, Ferguson HM Colonization of malaria vectors under semi-field conditions as a strategy for maintaining genetic and phenotypic similarity with wild populations Malar J,
    • Gregory Lanzaro: Adaptive introgression in an African malaria mosquito coincident with the increased usage of insecticide-treated bed nets 2015 Norris LC, Main BJ, Lee Y, Collier T, Fofana A, Cornel AJ, Lanzaro GC. Adaptive introgression in an African malaria mosquito coincident with the increased usage of insecticide-treated bed nets Proc Natl Acad Sci U S A,

    Most Recent 5 Book Chapters

    2013 Lanzaro GC, Lee Y: Chapter 6. Speciation in Anopheles gambiae - The distribution of genetic polymorphism and patterns of reproductive isolation among natural populations, Manguin S, (ed), Anopheles mosquitoes - New insights into malaria vectors. 173-96.

    2011 Dorn P, Noireau F, Krafsur ES, Lanzaro GC, Cornel AJ: Chapter 18: Genetics of major insect vectors, Tibayrenc M, (ed), Genetics and Evolution of Infectious Disease, London / Burlington, MA. .

    2005 Lanzaro GC, Nuzhdin S, Tripet F: Tools for monitoring the genetic structure and stability of mosquito populations, , In: Proceedings: Working Group on Strategic Plan to Bridge Laboratory and Field Research In Disease Vector Control 14-16 July 2004, ICIPE, Nairobi, Kenya, The Netherlands. .

    2003 Lanzaro, GC, Tripet, F: Gene flow among populations of Anopheles gambiae: A critical review, Takken, W, Scott, TW, (ed), Ecological Aspects for the Application of Genetically Modified Mosquitoes, Wageningen, The Netherlands. 109-132.