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  • Photo: Helen Raybould

    Helen Raybould- BS, PhD
    Professor and Researcher
    Anatomy, Physiology & Cell Biology

    2021 Vet Med 3B
    Davis, CA 95616

    +1 530 754 6555
    heraybould@ucdavis.edu

       

    Research Focus

    I am an intergrative physiologist with training in neurophysiology and gastrointestinal physiology. My research focuses on understanding the mechanisms by which gut luminal contents are sensed by chemosensing cells in the epithelium and activation of the vagal afferent (gut-brain) pathway. The research focuses on how both nutrients and bacterially-derived factors activate gut endocrine cells and how this information is transmitted to the brain to alter GI function and food intake. We study how these pathways are altered in metabolic disease, including obesity and type 2 diabetes. The research focuses on alterations in the gut microbiota and intestinal permeability in obesity, and how these factors may drive changes in the gut-brain pathway. We also work on the beneficial effects of prebiotic milk oligosaccharides and prebiotic bacteria in metabolic disease.

    Education

    1977 BS Biological Sciences, University of Birmingham, UK,
    1986 PhD Gastrointestinal Physiology, University of Liverpool, UK,

    Honors and Awards

    2008 Outstanding Women in Gastroenterology, American Gastroenterology Association Institute

    Active Research Grants

    Principal Investigator, Cholecystokinin: role in postprandial gastric motility, (Principal Investigator), NIH DDK

    Principal Investigator, Activation of probiotic bacteria by milk glycans, (Principal Investigator), NIH NCCIH

    Co-Investigator, UC Davis Mouse Metabolic Phenotyping Center , K. Lloyd (Principal Investigator), NIH DDK

    Most Recent 10 Publications

    • Helen Raybould: Bovine milk oligosaccharides decrease gut permeability and improve inflammation and microbial dysbiosis in diet-induced obese mice. 2017 Boudry, G, Hamilton, MK, Chichlowski, M, Wickramasinghe, S, Barile, D, Kalanetra, KM, Mills, DA, Raybould, HE Bovine milk oligosaccharides decrease gut permeability and improve inflammation and microbial dysbiosis in diet-induced obese mice. Journal of dairy science,
    • Helen Raybould: Prebiotic milk oligosaccharides prevent development of obese phenotype, impairment of gut permeability, and microbial dysbiosis in high fat-fed mice. 2017 Hamilton, MK, Ronveaux, CC, Rust, BM, Newman, JW, Hawley, M, Barile, D, Mills, DA, Raybould, HE Prebiotic milk oligosaccharides prevent development of obese phenotype, impairment of gut permeability, and microbial dysbiosis in high fat-fed mice. American journal of physiology. Gastrointestinal and liver physiology,
    • Helen Raybould: Curricular Revision and Reform: The Process, What Was Important, and Lessons Learned. 2017 Ilkiw, JE, Nelson, RW, Watson, JL, Conley, AJ, Raybould, HE, Chigerwe, M, Boudreaux, K Curricular Revision and Reform: The Process, What Was Important, and Lessons Learned. Journal of veterinary medical education,
    • Helen Raybould: Nopal feeding reduces adiposity, intestinal inflammation and shifts the cecal microbiota and metabolism in high-fat fed rats. 2017 Moran-Ramos, S, He, X, Chin, EL, Tovar, AR, Torres, N, Slupsky, CM, Raybould, HE Nopal feeding reduces adiposity, intestinal inflammation and shifts the cecal microbiota and metabolism in high-fat fed rats. PloS one,
    • Helen Raybould: Enterocyte glycosylation is responsive to changes in extracellular conditions: implications for membrane functions. 2017 Park, D, Xu, G, Barboza, M, Shah, IM, Wong, M, Raybould, H, Mills, DA, Lebrilla, CB Enterocyte glycosylation is responsive to changes in extracellular conditions: implications for membrane functions. Glycobiology,
    • Helen Raybould: Milk with and without lactoferrin can influence intestinal damage in a pig model of malnutrition. 2016 Garas, LC, Feltrin, C, Hamilton, MK, Hagey, JV, Murray, JD, Bertolini, LR, Bertolini, M, Raybould, HE, Maga, EA Milk with and without lactoferrin can influence intestinal damage in a pig model of malnutrition. Food & function,
    • Helen Raybould: Bugs, guts and brains, and the regulation of food intake and body weight. 2016 Hamilton, MK, Raybould, HE Bugs, guts and brains, and the regulation of food intake and body weight. International journal of obesity supplements,
    • Helen Raybould: Changes in intestinal barrier function and gut microbiota in high-fat diet-fed rats are dynamic and region dependent 2015 Hamilton MK, Boudry G, Lemay DG, Raybould HE Changes in intestinal barrier function and gut microbiota in high-fat diet-fed rats are dynamic and region dependent Am J Physiol Gastrointest Liver Physiol,
    • Helen Raybould: Chronic exposure to low dose bacterial lipopolysaccharide inhibits leptin signaling in vagal afferent neurons. 2015 de La Serre CB, de Lartigue G, Raybould HE Chronic exposure to low dose bacterial lipopolysaccharide inhibits leptin signaling in vagal afferent neurons. Physiol Behav,
    • Helen Raybould: Glucagon-like peptide 1 interacts with ghrelin and leptin to regulate glucose metabolism and food intake through vagal afferent neuron signaling 2015 Ronveaux CC, Tomé D, Raybould HE Glucagon-like peptide 1 interacts with ghrelin and leptin to regulate glucose metabolism and food intake through vagal afferent neuron signaling J Nutr,

    Most Recent 5 Book Chapters

    2012 De Lartigue G, Raybould HE: The Gastrointestinal Tract and Control of Food Intake, Johnson, (ed), Physiology of The Gastrointestinal Tract. 1963-1078.

    2009 Pandol SJ, Raybould HE, Yee HF: Integrative responses of the gastrointestinal tract and liver to a meal, Yamada T, (ed), Textbook of Gastroenterology, Oxford, UK. .

    2008 Barrett K, Raybould HE: Section VI: Gastrointestinal physiology, Koeppen BM, Stanton BA, (ed), Berne and Levy Physiology. .

    2003 Raybould HE, Pandol SJ, Yee H: The integrative responses of the gastrointestinal tract and liver to a meal, Yamada T, Alpers DH, Kaplowitz N, Laine L, Owyang C, Powell DW, (ed), Textbook of Gastroenterology, Philadelphia, PA. 1-12.

    1999 Raybould HE: CCK: hormonal and neurocrine regulator of postprandial gastrointestinal function, Greeley, G., (ed), Gastrointestinal Endocrinology, New Jersey. 161-181.