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    Laura Van Winkle- BS, PhD
    Professor and Professor in Residence
    Anatomy, Physiology & Cell Biology

    508 CHE
    Davis, CA 95616

    +1 530 754 7547
    lsvanwinkle@ucdavis.edu

       

    Research Focus

    The role of sex-differences and xenobiotic metabolism in lung pathology and toxicology. Air pollution including tobacco smoke, particulates and ozone. Growth factors and cell-cell interactions in lung wound healing, in lung disease (lung cancer and asthma) and during lung development. Cell proliferation and progenitor cells. Microscopes and imaging methods.

    Specialty Focus

    Toxicology of the lung. Diplomate American Board of Toxicology (DABT)

    Education

    1987 BS Pharmacology, University of California, Santa Barbara
    1995 PhD Pharmacology and Toxicology, University of California, Davis

    Honors and Awards

    1997-1999 American Lung Association Research Fellow
    1995-1997 NHLBI Pulmonary Postdoctoral Training Fellowship
    1994 Robert Emrie Smith Memorial Research Fellowship in Physiology
    1993-1995 NIEHS Training Fellowship in Environmental Toxicology
    1992-1993 Graduate Fellowship in Environmental Health Sciences

    Licenses

    Diplomate American Board of Toxicology (General Toxicology)

    Active Research Grants

    Principal Investigator, Metabolic mechanisms of naphthalene toxicity in lung, (Principal Investigator), NIH/NIEHS/NHLBI

    Co-Investigator, UC Davis Core Center in Environmental Health Sciences, Hertz-Piccioto (Principal Investigator), NIEHS

    Principal Investigator, Lung Toxicity from 4-methylindoleamine, (Principal Investigator), American Beverage Association

    Principal Investigator, ViCTER Supplement to R01 Metabolic mechanisms of naphthalene toxicity in lung, (Principal Investigator), NIEHS/NHLBI

    Most Recent 10 Publications

    • Laura Van Winkle: Naphthalene cytotoxicity in microsomal epoxide hydrolase deficient mice. 2016 Carratt SA, Morin D, Buckpitt AR, Edwards PC, Van Winkle LS Naphthalene cytotoxicity in microsomal epoxide hydrolase deficient mice. Toxicology letters,
    • Laura Van Winkle: Novel multi-functional europium-doped gadolinium oxide nanoparticle aerosols facilitate the study of deposition in the developing rat lung. 2016 Das GK, Anderson DS, Wallis CD, Carratt SA, Kennedy IM, Van Winkle LS Novel multi-functional europium-doped gadolinium oxide nanoparticle aerosols facilitate the study of deposition in the developing rat lung. Nanoscale,
    • Laura Van Winkle: Aerosolized Silver Nanoparticles in the Rat Lung and Pulmonary Responses over Time. 2016 Silva RM, Anderson DS, Peake J, Edwards PC, Patchin ES, Guo T, Gordon T, Chen LC, Sun X, Van Winkle LS, Pinkerton KE Aerosolized Silver Nanoparticles in the Rat Lung and Pulmonary Responses over Time. Toxicologic pathology,
    • Laura Van Winkle: Cardiac ischemia reperfusion injury following instillation of 20nm citrate-capped nanosilver 2015 Holland NA, Becak DP, Shannahan JH, Brown JM, Carratt SA, Van Winkle LS, Pinkerton KE, Wang CM, Musamy P, Baer DR, Sumner SJ, Fennell TR, Lust RM, Wingard CJ Cardiac ischemia reperfusion injury following instillation of 20nm citrate-capped nanosilver J Nanomedicine and Nanotechology,
    • Laura Van Winkle: Influence of particle size on persistence and clearance of aerosolized silver nanoparticles in the rat lung. 2015 Anderson DS, Patchin ES, Silva RM, Uyeminami DL, Sharmah A, Guo T, Das GK, Brown JM, Shannahan J, Gordon T, Chen LC, Pinkerton KE, Van Winkle LS Influence of particle size on persistence and clearance of aerosolized silver nanoparticles in the rat lung. Toxicol Sci,
    • Laura Van Winkle: Persistence of silver nanoparticles in the rat lung: Influence of dose, size, and chemical composition. 2015 Anderson DS, Silva RM, Lee D, Edwards PC, Sharmah A, Guo T, Pinkerton KE, Van Winkle LS Persistence of silver nanoparticles in the rat lung: Influence of dose, size, and chemical composition. Nanotoxicology,
    • Laura Van Winkle: Evolution of silver nanoparticles in the rat lung investigated by X-ray absorption spectroscopy. 2015 Davidson RA, Anderson DS, Van Winkle LS, Pinkerton KE, Guo T Evolution of silver nanoparticles in the rat lung investigated by X-ray absorption spectroscopy. The journal of physical chemistry. A,
    • Laura Van Winkle: Alterations in the proteome of the respiratory tract in response to single and multiple exposures to naphthalene. 2015 K├╝ltz D, Li J, Sacchi R, Morin D, Buckpitt A, Van Winkle L Alterations in the proteome of the respiratory tract in response to single and multiple exposures to naphthalene. Proteomics,
    • Laura Van Winkle: Single-Cell Mechanics Provides an Effective Means To Probe in Vivo Interactions between Alveolar Macrophages and Silver Nanoparticles. 2015 Liu YX, Karsai A, Anderson DS, Silva RM, Uyeminami DL, Van Winkle LS, Pinkerton KE, Liu GY Single-Cell Mechanics Provides an Effective Means To Probe in Vivo Interactions between Alveolar Macrophages and Silver Nanoparticles. The journal of physical chemistry. B,
    • Laura Van Winkle: Pulmonary effects of silver nanoparticle size, coating, and dose over time upon intratracheal instillation. 2015 Silva RM, Anderson DS, Franzi LM, Peake JL, Edwards PC, Van Winkle LS, Pinkerton KE Pulmonary effects of silver nanoparticle size, coating, and dose over time upon intratracheal instillation. Toxicological sciences : an official journal of the Society of Toxicology,

    Most Recent 5 Book Chapters

    2015 Pinkerton KE, Van Winkle LS, Plopper CG, Smiley-Jewell S, Covarrubias EC, McBride JT: Architecture of the Tracheobronchial Tree, Parent (ed): Pinkerton, Van Winkle, Plopper eds section 1, , Comparative Biology of Normal Lung, 2nd edition. .

    2010 Pinkerton KE, Smiley-Jewell S, Van Winkle LS: Tracheobronchial airways, Yost et al, (ed), Toxicology of the Respiratory System, Comprehensive Toxicology, 2nd Edition. .

    2010 Van Winkle LS: Cell damage and cell renewal in the lung, Yost et al, (ed), Toxicology of the Respiratory System, Comprehensive Toxicology, 2nd Edition. .

    2008 Plopper CG, Smiley-Jewell SM, Miller LA, Fanucchi MV, Evans MJ, Buckpitt AR, Avdalovic M, Gershwin LJ, Joad JP, Kajekar R, Larson S, Pinkerton KE, Van Winkle LS, Schelegle ES, Pieczarka EM, Wu R, Hyde DM: Primate Models of Allergic Asthma, Kay AB et al, (ed), Allergy and Allergic Diseases, London. Chapter 54.

    2008 Hyde DM, Miller LA, Schelegle ES, Fanucchi MV, Van Winkle LS, Tyler NK, Avdolovic MV, Evans MJ, Kajekar R, Buckpitt AR, Pinkerton KE, Joad JP, Gershwin LJ, Wu R, Plopper CG: Chronic airway disease in nonhuman primates, Voelkel & MacVee, (ed), Chronic Obstructive Lung Disease. Chapter 17.