This animation shows the principle of the clinical trial. Under general anesthesia, a guide pedestal is secured to the animals skull over the tumor and is used to allow accurate placement of small glass catheters directly into the tumor. The experimental chemotherapy is infused into the tumor after which the catheter is removed and the animal is recovered from anesthesia. The pedestal is left in pace to allow for subsequent treatments.


For information on enrollment, or to refer a patient:

Neurology/Neurosurgery Service
ChristyChessman (Service coordinator)
530 754 0606

VMTH Hospital Reception
530 752 1393

Peter J. Dickinson, BVSc, PhD, DACVIM (Neurology)
UC Davis
School of Veterinary Medicine
(530) 752-3412



Convection-Enhanced Delivery of Liposomal CPT-11 with Real-Time MRI in Canine Primary Gliomas.

This is a collaborative clinical trial between UC Davis Veterinary School and the Dept of Neurosurgery at UCSF. The trial involves infusion of chemotherapy (CPT-11) directly into brain tumors, resulting in very high drug concentrations in the tumor with minimal adverse effects. To achieve similar concentrations with conventional systemic delivery would result in marked toxicity. The study also allows the clinician to accurately follow exactly where the infused chemotherapy is going in the brain. Liposomal CPT-11 is about to enter human brain tumor clinical trials.

For more information about CPT-11 Click

The CPT-11 clinical trial has been approved by :

VMTH Clinical Trial Review Board
UC Davis Institutional Animal Use and Care Committee

We will be happy to review imaging data, diagnostics or clinical history for potential cases.

The Clinical trial is funded by the National Institutes of Health (NIH)
Dogs enrolled in the study will have all treatment procedures and MRI scans paid for

CBS News story on our treatment of
dogs in the CPT-11 clinical trial.